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ea0032p201 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Changes of expression of regulators of calcification in different stages of atherosclerosis in vasculature and bone

Schweighofer Natascha , Aigelsreiter Ariane , Graf-Rechberger Martina , Hacker Nicole , Schweiger Martin , Trummer Olivia , Pieber Thomas , Ulbing Matthias , Muller Helmut , Obermayer-Pietsch Barbara

Calcification is physiologically present in bone but also pathophysiologically in the vasculature, favouring cardiovascular diseases. Our aim was to investigate changes in the expression of calcification regulators (CR) during vascular calcification in bone and vasculature. Gene expression levels of OPG, RANKL, OPN, MGP, BSP-II and RUNX2 were determined in bone, aorta and arteria ilica externa tissue samples of 22 transplant donors. Gene expression levels during atheroscleroti...